Equipment and Accessories for Modern High-Effective Technology of Ozone Therapy and Ozone prophylaxis
Equipment and Accessories for Modern High-Effective Technology of Ozone Therapy and Ozone prophylaxis
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General Information
Since ozone is used as a medicine, like for any other therapeutic agent you should know precise ozone concentration, total dose and exposure time in order to minimize the toxic effect of ozone on the organism and to increase its therapeutic efficiency. Of great importance is ozone concentration in ozone/oxygen gas mixture.
Extremely low ozone concentrations do not produce a toxic effect since radicals have been quickly and completely neutralized, but at the same time they are not always as much effective as necessary. On the other hand, extremely high ozone concentrations induce biological activity, but imply cytotoxicity.
In the medicine ozone has been used in the form of ozone/oxygen gas mixture within the range of ozone concentrations from 50 to 10000 mcg/L as recommended by the Russian Association of Ozone Therapy.
The fundamentals of ozone therapy are based on the known properties of ozone as follows:
- high ozone concentrations from 2000 mcg/L and higher have a wound cleaning effect;
- low ozone concentrations less than 2000 mcg/L have a wound healing effect;
- high doses of ozone 4000-6000 mcg suppress immune reactions (immunosuppression);
- low doses of ozone have an immunostimulating effect;
- high doses of ozone have a blood-stopping effect;
- low doses of ozone have a stimulating effect on blood circulation;
- in any case you should follow the principle - always start with lower ozone concentrations and only after observing the patient's reaction gradually increase ozone concentrations.
According to the above mentioned the doctor should be confident that it is expedient to prescribe ozone therapy exactly for this patient. For each clinical case it is advisable to develop the individual program of ozone treatment including the optimal daily dose of ozone, frequency of procedures, duration of treatment course, methods of ozone therapy.
One of the important treatment parameters is the dose of ozone that should not exceed the potential of antioxidant enzymes.
One of the important treatment parameters is the dose of ozone that should not exceed the potential of antioxidant enzymes.
The scientifically determined total dose per day is 3000 mcg of ozone. The total daily dose includes quantities of ozone received by the patient during different procedures of ozone therapy within a day. For example, rectal ozone insufflation 900 mcg + subcutaneous ozone injections into the biologically active points 50 mcg. So, the patient received 950 mcg of medical ozone.
Dose of ozone (mcg) = ozone concentration delivered by ozone generator (mcg/L) x volume of ozone (L)
1. Example of dosage for minor AHT with ozone in acneiform eruption.
The patient should receive 100 mcg of ozone. For this purpose take into a syringe the ozone/oxygen gas mixture at ozone concentration of 10000 mcg/L and volume of 10 ml.
2. Example of dosage for major AHT in bronchial asthma.
The patient should receive 1000 mcg of ozone. For this purpose add into the container with autoblood 100 ml of ozone/oxygen gas mixture at ozone concentration of 10000 mcg/L.
The patient should receive 100 mcg of ozone. For this purpose take into a syringe the ozone/oxygen gas mixture at ozone concentration of 10000 mcg/L and volume of 10 ml.
2. Example of dosage for major AHT in bronchial asthma.
The patient should receive 1000 mcg of ozone. For this purpose add into the container with autoblood 100 ml of ozone/oxygen gas mixture at ozone concentration of 10000 mcg/L.
As an exception is considered the use of high doses of ozone 4000-6000 for major AHT to achieve immunosuppression in viral hepatitis, rheumatic diseases, herpetic infection.
The frequency of procedures can be different. Intravenous infusions of ozonated saline should be performed daily or every two days. Major AHT should be performed every 2-3 days, minor AHT usually every two days. An exception is made for generalized infection of different genesis when different methods of ozone therapy can be used within one day.
For example, locally can be performed a treatment with ozone/oxygen gas mixture or ozonized water in a special chamber plus intravenous infusion of ozonated saline for systemic effect. The duration of treatment course depends on the severity grade, kind of disease etc. In spite of existing treatment protocols the frequency and number of procedures should be if possible determined individually.
The frequency of procedures can be different. Intravenous infusions of ozonated saline should be performed daily or every two days. Major AHT should be performed every 2-3 days, minor AHT usually every two days. An exception is made for generalized infection of different genesis when different methods of ozone therapy can be used within one day.
For example, locally can be performed a treatment with ozone/oxygen gas mixture or ozonized water in a special chamber plus intravenous infusion of ozonated saline for systemic effect. The duration of treatment course depends on the severity grade, kind of disease etc. In spite of existing treatment protocols the frequency and number of procedures should be if possible determined individually.
The achieved positive results of treatment after ozone therapy can be kept on average from 5 to 7 months depending on the kind, form and stage of disease. That means it is recommended to repeat treatment courses 2-3 times a year to support the received therapeutic effect.
Ozone therapy is characterized by after-effect i.e. the patients notice changes in their state some time later after the end of treatment course. This phenomenon can be explained so that the increased point of oxyhemoglobin reduction time decreases very slowly, within several weeks. Thus, the high level of oxygen in the blood exerts a therapeutic influence even after the treatment course has been finished.
For patients with somatic pathology before ozone therapy it is necessary to collect the complete anamnesis on availability of any chronic infection. The matter is that ozone is able to aggravate these processes. In this situation it is necessary to continue ozone therapy that facilitates the arrest of inflammation. In some cases it can be necessary to use additional medicines.
Ozone therapy is characterized by after-effect i.e. the patients notice changes in their state some time later after the end of treatment course. This phenomenon can be explained so that the increased point of oxyhemoglobin reduction time decreases very slowly, within several weeks. Thus, the high level of oxygen in the blood exerts a therapeutic influence even after the treatment course has been finished.
For patients with somatic pathology before ozone therapy it is necessary to collect the complete anamnesis on availability of any chronic infection. The matter is that ozone is able to aggravate these processes. In this situation it is necessary to continue ozone therapy that facilitates the arrest of inflammation. In some cases it can be necessary to use additional medicines.
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In Different Fields Of Medicine
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FAQ
You've brought up the problem of toxic impurities possibly containing in the delivered ozone/oxygen mixture. Is it really so important?
Every doctor using ozone therapy must be sure of its safety, thus there must be no doubt about the purity of delivered ozone/oxygen gas mixtures for medical use (they should be contaminant-free).
We consider this problem as very important. It is a fact that after approx. 100 hours of continuous operation owing to the electrochemical erosion of the ozonization chamber walls and electrodes some of available ozone generators deliver an ozone/oxygen gas mixture contaminated by impurities (calcium, aluminium, silicon, magnesium, copper etc) in concentrations considered as dangerous for the health that however can become evident even some months or years after the treatment. This claim is valid through the investigation of the upper layer taken from the ozonization chamber wall. There are only two possible reasons for the products which were found out on the wall:
Parenteral methods of ozone therapy are safe only if the ozone generator delivers pure contaminant-free medical ozone. Each medical ozone generator should be equipped with a filter for extra purification of oxygen used; purity of delivered ozone/oxygen gas mixtures should be guaranteed by the manufacturer through available test protocols, the same is about accuracy in maintaining the chosen ozone concentration (not worse than 10%) and great operation resource (durability) of ozonization chamber (without any decrease in the ozone production and without any change in ozone concentration accuracy) for at least 2000 hours of continuous operation.
We consider this problem as very important. It is a fact that after approx. 100 hours of continuous operation owing to the electrochemical erosion of the ozonization chamber walls and electrodes some of available ozone generators deliver an ozone/oxygen gas mixture contaminated by impurities (calcium, aluminium, silicon, magnesium, copper etc) in concentrations considered as dangerous for the health that however can become evident even some months or years after the treatment. This claim is valid through the investigation of the upper layer taken from the ozonization chamber wall. There are only two possible reasons for the products which were found out on the wall:
- Destruction of the electrodes (the discovered products are equivalent to the materials of electrodes);
- Fine contaminants possibly containing in oxygen which during the ozonolysis can be converted into toxic products.
Parenteral methods of ozone therapy are safe only if the ozone generator delivers pure contaminant-free medical ozone. Each medical ozone generator should be equipped with a filter for extra purification of oxygen used; purity of delivered ozone/oxygen gas mixtures should be guaranteed by the manufacturer through available test protocols, the same is about accuracy in maintaining the chosen ozone concentration (not worse than 10%) and great operation resource (durability) of ozonization chamber (without any decrease in the ozone production and without any change in ozone concentration accuracy) for at least 2000 hours of continuous operation.
What do you think about oxygen concentrators used as Oxygen Supply Systems for medical ozone generators?
There is no definite opinion at this point. Oxygen produced by these devices very seldom reaches the purity of 95% and higher, and we don not know whether the remaining 5% of content would not be dangerous due to electric synthesis in the ozonization chamber or interaction with ozone.
As you know, medical ozone generators require the use of medical oxygen referred to oxygen gas with guaranteed purity of 99,9% and higher. Anyways, we do not mind the use of oxygen concentrators for external i.e. local methods of ozone therapy.
As you know, medical ozone generators require the use of medical oxygen referred to oxygen gas with guaranteed purity of 99,9% and higher. Anyways, we do not mind the use of oxygen concentrators for external i.e. local methods of ozone therapy.
Would you please explain a necessity for a built-in oxygen filter in medical ozone generators?
Our previous experience has shown that oxygen used can contain micro-quantities of technical oils, thus each ozone generator intended for medical use should be equipped with a filter for extra purification of oxygen that inhibits the introduction of technical oils possibly containing in oxygen into the ozonization chamber. During the ozonolysis technical oils can be converted into dangerous toxic products (fatty acids, ketones, aldehydes etc).
Within a long operation time of ozone generator great volumes of oxygen are conveyed through the ozonization chamber (within 100 hours of operation in case of saline ozonization at a flow-rate of 1 L/min approx. 6000 L of oxygen are conveyed through the ozonization chamber), the ozonization chamber gradually becomes covered with an oily layer, and the doctor cannot be sure of the quality of gas mixtures delivered, thus extra purification of oxygen through a filter at the inlet of ozone generator is a reasonable step.
Within a long operation time of ozone generator great volumes of oxygen are conveyed through the ozonization chamber (within 100 hours of operation in case of saline ozonization at a flow-rate of 1 L/min approx. 6000 L of oxygen are conveyed through the ozonization chamber), the ozonization chamber gradually becomes covered with an oily layer, and the doctor cannot be sure of the quality of gas mixtures delivered, thus extra purification of oxygen through a filter at the inlet of ozone generator is a reasonable step.
Would you please explain the parameter "Range of selecting the dose of ozone"?
It is puzzling to us that some manufacturers of medical ozone generators use the parameter "Ozone production per 1 hour". This parameter was obviously taken from the ozone technology for water treatment, but in the medicine the ozone production should be adjustable at least per 1 min
How important is the accuracy of +/-5% … +/-10% in maintaining the chosen ozone concentration and the adjustable range 1 : 9950, as far as I know, recently these parameters have not been taken into consideration?
Before the New-Generation of medical ozone machines characterized by unique accuracy in maintaining the chosen ozone concentration and a uniquely wide range of ozone concentration adjustment, the doctors using ozone therapy were conditioned by the "traditional" types of ozone generator with very low accuracy in maintaining the chosen ozone concentration (worse than 40-50% as a rule) and a narrow adjustable range (1 : 15 - from 1 mg/l to 15 mg/l). The ozone concentration accuracy of +/-5% …+/-10% ensures a reasonable, predictable and dose-related therapy.
The high accuracy in maintaining the chosen ozone concentration allows using ozone like any other generally accepted medicine. That might have been one of the obstacles for wide spreading of ozone therapy. Nevertheless, all advantages of the Medozons machine do not influence its price, but this is a fact that there are many medical ozone generators on the market being much more expensive, but inferior in technical properties as compared with our machines.
The high accuracy in maintaining the chosen ozone concentration allows using ozone like any other generally accepted medicine. That might have been one of the obstacles for wide spreading of ozone therapy. Nevertheless, all advantages of the Medozons machine do not influence its price, but this is a fact that there are many medical ozone generators on the market being much more expensive, but inferior in technical properties as compared with our machines.
The parameters "Range of ozone concentration adjustment 1:9950" and "Range of selecting the dose of ozone 0,25 … 10000" are not clear to us.
Would you please explain it?
Would you please explain it?
We can explain it with the Medozons-BM:
So, medical ozone generators of Medozons series are able to produce guaranteed pure medical ozone and dose it exactly, with regards to technical and medical features they are the best ones within Russia and have no analogies worldwide! We are sure that the above parameters today considered as unique tomorrow will be the new standards of ozone therapy.
- Range of delivered ozone concentrations (50…10 000) mcg/L. This parameter means that the machine is able to maintain the chosen ozone concentration within the available range with accuracy not worse than +/- 10%: 107 mcg/L or 5671 mcg/L.
- The parameter "Range of ozone concentration adjustment (1 : 9950)" means that the machine is able to provide 9950 values/gradations of ozone concentration with accuracy +/-10% that characterizes the depth of adjustment.
- The range of selecting the dose of ozone characterizes a wide range of ozone dosage adjustment from 0,25 mcg/L to 10000 mcg/L with accuracy +/-5%, at an ozone/oxygen flow-rate of 0,25 L/min adjustable by step 0,25 mcg; 0,5 L/min - 0,5 mcg; 1 L/min - 1 mcg.
So, medical ozone generators of Medozons series are able to produce guaranteed pure medical ozone and dose it exactly, with regards to technical and medical features they are the best ones within Russia and have no analogies worldwide! We are sure that the above parameters today considered as unique tomorrow will be the new standards of ozone therapy.
Would you please explain a necessity for an automated system of ozone-oxygen flow-rate adjustment, what about doing it manually by means of oxygen flow regulator? The use of fixed flow-rates (0,25; 0,5; 1,0 L/min) may limit the range of ozone applications.
Manually setting of oxygen flow-rate by means of regulator may induce a considerable decrease in ozone dosage accuracy (the dose of ozone = CO3 x O2/O3 flow-rate x treatment time) due to possible oxygen pressure fluctuations (in oxygen tank or any other oxygen supply system) or any change in gas tract resistance.
In medical ozone generators of Medozons series oxygen flow-rate delivered to the ozonization chamber is automatically stabilized at the given level regardless of influence from outside, the automated stabilization system of oxygen flow-rate is reliable even in case of considerable pressure fluctuations that ensures a dose-related therapy. The automatic gas supply system is tested by the manufacturer for accuracy in maintaining the chosen oxygen flow-rate. We are convinced that the fixed O2/O3 flow-rates do not limit, but widen the range of ozone applications, most of doctors perform ozone therapy at a flow-rate of 1 L/min, but using a flow-rate of 0,5 or 0,25 L/min it is possible to successfully perform intracavitary ozone therapy (in gynecology, urology etc).
In medical ozone generators of Medozons series oxygen flow-rate delivered to the ozonization chamber is automatically stabilized at the given level regardless of influence from outside, the automated stabilization system of oxygen flow-rate is reliable even in case of considerable pressure fluctuations that ensures a dose-related therapy. The automatic gas supply system is tested by the manufacturer for accuracy in maintaining the chosen oxygen flow-rate. We are convinced that the fixed O2/O3 flow-rates do not limit, but widen the range of ozone applications, most of doctors perform ozone therapy at a flow-rate of 1 L/min, but using a flow-rate of 0,5 or 0,25 L/min it is possible to successfully perform intracavitary ozone therapy (in gynecology, urology etc).
How would you explain the fact that your ozone generators are not equipped with a measuring device to determine the delivered ozone concentration? To my mind, this can discredit the method of ozone therapy. From my own experience I know that at the starting point any medical ozone generator has the actual accuracy of delivered ozone concentration +/-40…+/-80%.
In medical ozone generators of Medozons series like Medozons-BM and BM-02 you can see a different functional principle of the ozonization chamber that ensures a wide range of ozone concentration adjustment (from 50 to 10000 mcg/L) with high accuracy in automatically maintaining the chosen ozone concentration not worse than +/- 10%, in fact, the actual accuracy tested by the manufacturer is not worse than +/- 5%. The attested accuracy is valid for at least the same time as the specified durability of the ozonization chamber before the scheduled prophylactic service (2000 hours of continuous operation or about 5 years of usage). The latest device Medozons-System has a built-in measurer of ozone concentratrions.
© MEDOZONS Ltd., 2009
Ul. B.Panina 9 * 603089 Nizhny Novgorod / Russia
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N.B. The information on our website is intended for medical professionals, since ozone therapy and medical ozone generators should be used in a clinical setting under the supervision of a medical doctor.