The Russian Technology of Ozone Therapy

There are two main schools of ozone therapy in the world - the Western (originally German or European) based on high ozone concentrations and mostly focused on immediate and instant effect, and the Russian based on much lower, but therapeutically effective and most importantly safe ozone concentrations oriented to remote and prolonged effect. The Russian school is against using high ozone concentrations by following the most important principle of medicine - "not to harm".

According to Prof. Peretyagin, M.D. (President of the Russian Association of Ozone Therapy), therapeutically active and safe ozone concentrations for systemic effects on the human body range from 50 to 10 000 mcg/L (0,05 to 10 mcg/ml), higher ozone concentrations can be dangerous for patients by causing such side-effects as phlebitis, haemolysis, immune suppression, disturbances of the enzymatic system etc. He compares high-dosed ozone therapy with a "knout" that whips on the body's antioxidant system leading to its exhaustion.

According to Prof. Peretyagin "... ozone therapy with low ozone concentrations is a far-sighted ideology oriented to remote results and next generations of patients. We all know the unhappy story with antibiotics, many pharmaceutical companies are involved in the development of next generation of antibiotics since the external and internal flora of the human body has got resistant to the previous generations. The same can happen to ozone used at the highest level because highly dosed ozone is a powerful activator for all body systems, and if the body achieves the maximum level at once, it will adapt to this and next time will require more, but the therapeutically active and safe range of ozone concentrations is limited ..."

Why to use high ozone concentrations if even better therapeutic effects can be achieved with low safe ozone concentrations? Besides, the more important thing is not ozone concentration, but dose of ozone given to the patient, and a therapeutic effect is better if the needed dose is given to the patient not at once, but gradually step by step. For example, for major AHT it is certainly important not ozone concentration set on the ozone machine, but dose of ozone given to the patient that depends not only on the concentration, but also on the volume of gas mixture:

Worldwide the dose of ozone used for major AHT ranges from 500 to 3000 mcg of ozone, but during over 30 years' clinical experience our doctors very rarely used the dose higher 1000 mcg (only in exceptional cases like severe viral conditions to inactivate the virus at the primary stage, for example hepatitis, HIV, AIDS etc.). Besides, you should know that high doses of ozone must be used under strict control of anti- and prooxidant systems and if necessary in combination with antioxidant therapy to prevent an oxidative stress and fast exhaustion of antioxidant resource of the human body (increased production of free radicals and decreased efficacy of the antioxidant system inactivating them), so we recommend to use an appropriate control device like FRAS (Free-Radical Analytical System) or BChL (Program-Methodcal System for Biochemiluminescence Analysis). Besides, for chronic patients who every 3-6 months need to repeat a treatment course of ozone therapy it is very important to use low doses of ozone, primarily because it is proved that if the human body receives the maximum active dose of ozone at once, next time its reaction to the same dose will be less, but the therapeutically active and safe range of ozone therapy is limited that means with time ozone therapy will be less and less effective for such patients.

Prof. Peretyagin is absolutely convinced that if there is an approach allowing to achieve positive clinical effects in different diseases within a low range of ozone doses, this one should be a method of choice.

The priority of the Russian school of ozone therapy is the wide use of ozonated saline drips – a systemic method of ozone therapy considered as a genuine alternative to major autohaemotherapy and rectal ozone insufflations. For the patient this method provides comfort during the procedure, hygienic safety and better therapeutic effects. More and more doctors worldwide estimate the benefits of the Russian method: simple and patient-friendly performance, strictly dose-related therapy, excellent therapy hygiene (no risk of contamination). This method is based on much longer and gentle contact of ozone dissolved in physiological solution with the internal environment of the patient when ozone drop by drop, molecule by molecule is introduced into the blood circulation and immediately reacts with the blood components, so the whole blood quantity being in circulation comes into contact with ozone thus providing much better and prolonged therapeutic effects. Based on the use of considerably lower ozone concentrations this method yields normalization of oxidoreduction potential of the organism. In case of initial prooxidant shift characteristic of acute inflammatory diseases it activates the antioxidant defense system (AOD) therefore producing an anti-inflammatory effect, on the contrary, in case of initial hyperactivity of AOD characteristic of chronic, sluggish process ozone induces a prooxidant shift therefore decreasing the level of AOD. In case of MAHT it's necessary to use antioxidants to prevent suppression of AOD. More and more European doctors formerly specialized in major autohaemotherapy have changed to the Russian method.

We recommend using ozonated saline prepared with ozone concentrations (in gas phase) from 500 to 5000 mcg/L (0,5 to 5 mcg/ml). According to our technology (saturation with ozone concentrations 1000-3000 mcg/L) the patient receives 40-120 mcg of ozone in 200 ml of saline. For sick or healthy human body it does make difference how hard we "whip" its fermentative systems with oxidative "knout". According to our technology direct delivery of low doses of ozone into the blood flow leads to direct reactions between ozone as oxidant and biosubstrates of blood and secondary reactions through activation of enzymatic systems, synthesis modulation and release of numerous endogenous BAS.

The safety and efficiency of the Russian approach of ozone therapy is valid through scientific and clinical evidence in different fields of medicine.

So, ozone administered by parenteral route involves the compensative mechanisms of human body to eliminate the disturbances of the homeostasis.

The method of intravenous ozonated saline infusions is based on the much longer contact of ozone with the internal environment of the patient that allows achieving positive therapeutic effects in different medical conditions by using considerably more low ozone concentrations and dosages compared with the Western school of ozone therapy. At the same time, the above-mentioned method allows at maximum using the powerful catalytic oxidative properties of ozone.

The correctness of the new method covering the most wide range of therapeutic action of ozone has been verified by the numerous fundamental biochemical, immunological, morphological, fine-structural, physiological and clinical studies. The use of ozonated saline solution induces an increase in the cell accumulation of biologically active compounds: phosphorylated nucleotides, regulator peptides, vitamins and amino acids.

Ozone used in low and medium concentrations induces an increase in the production of ATP, 2,3-DPG diphospoglycerate and NADPH₂ in the erythrocytes that particularly results in the reduction of oxidized glutathione, antioxidant enzyme glutathione-peroxidase; of clinical importance is the resulted normalization of lipid peroxidation, stabilization of the erythrocyte membranes at a structural-functional level and an increase in the deformability of the erythrocytes.

It is important to note that the Russian technology of ozone therapy has been successfully realized thanks to the New-Generation of ozone therapy machines that allow exactly varying the dosages of ozone within the extremely low range, which was formerly considered as therapeutically inactive.