Equipment and Accessories for Modern High-Effective Technology of Ozone Therapy and Ozone prophylaxis
Equipment and Accessories for Modern High-Effective Technology of Ozone Therapy and Ozone prophylaxis
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Ozone Therapy in the Obstetrics & Gynecology
Obstetrics and gynecology can be with certainty numbered among the fields of medicine where the whole spectrum of therapeutic properties of ozone can be successfully used. The list of indications for ozone therapy is as wide as the totality of medical problems requiring an improvement of macro- and microcirculation, correction of immunological status or lipid peroxidation processes.
Owing to the capacity of medical ozone to act on the basic links of pathogenesis, ozone therapy has proved to be particularly effective in the following pathologies:
Owing to the capacity of medical ozone to act on the basic links of pathogenesis, ozone therapy has proved to be particularly effective in the following pathologies:
- Spontaneous abortion;
- EPH-gestosis;
- Pregnancy anemia;
- Early toxicosis;
- Fetoplacental insufficiency;
- Inflammatory diseases of internal genital organs (adnexitis, endomyometritis);
- Inflammatory diseases of lower female genital organs (colpitis, endocervicitis, bacterial vaginosis);
- Oncogynecological pathology;
- Vulva dystrophy.
- Intrauterine fetus infection;
- Fatness-associated pregnancy complications .
The therapeutic effect of ozone is based on the well-known mechanisms of its biological action:
- Owing to its high oxidating power, highly concentrated ozone used at the local level produces a bactericidal, fungicidal and viricidal effect versus the most important species of gram-positive and gram-negative bacteria, viruses, pathogenic fungi and protista;
- The systemic effect of medium and low ozone concentrations produced by parenteral route of administration in medical conditions associated with hypoxia situations is based on the activation of the oxygen-dependent processes;
- The ozonides resulted from the ozonolysis of unsaturated fatty acids modify cell membranes at the structural-functional level, intensify the enzymatic systems and thereby improve the energy metabolism.
- The immunomodulating effect of ozone is based on its ability to activate the phagocytosis through the formation of peroxides and stimulation of the production of cytokines by lymphocytes and monocytes.
- Modification of blood corpuscle membranes and fine-structure of vascular bed as well as a decrease in the viscosity properties of blood lead to an improvement of the blood micro-flow and respiratory metabolism at the tissue level.
Before the practical use of ozone in clinics for women, the following fundamental facts were experimentally established:
- During the pregnancy ozone concentration in gas mixture bubbled into saline solution (method of intravenous drop-by-drop infusions of ozonated saline solution) may range within 400-800 mcg per liter. This result was obtained on the basis of investigations into the influence of different ozone concentrations on the parameters of lipid peroxidation and antioxidant defense system in blood samples taken from the patients with different obstetric pathologies (series of experiments in vitro).
- The safety of these ozone concentrations relating to teratogenecity was confirmed by a series of experiments in vivo on pregnant laboratory rats.
Further fundamental investigations have fully confirmed the applicability of ozone therapy in the treatment of gestational complications since it has been reliably established that the use of ozone leads to correction of basic links of the pathogenesis and the most important clinical appearances of disease:
- Improvement of macro- and microcirculation that results in the normalization of placenta hormonogenic function;
- Decrease in the activity of lipid peroxidation processes and simultaneous stimulation of the antioxidant defense system of human body;
- Immunomodulating action develops particularly through a decrease in blood level of circulating immune complexes, IgM, group and Rh antibodies, increase in the phagocytic activity of neutrophils;
- Decrease (if available) in the hypercoagulation activity of blood;
- Intensification of the protein-synthesizing function of liver;
- Ozone therapy exerts a beneficial influence on the clinical course of threatened abortion, gestosis, pregnancy anemia, fetoplacental insufficiency, reduces a risk of intrauterine fetus infection and a risk of fatness-associated pregnancy complications, improves a prognosis of these diseases;
- Ozone therapy reduces stationary treatment time, reduces the use of medicinal agents;
- Ozone therapy significantly reduces a risk of such complications as delivery weakness, postnatal and early postnatal bleedings;
- The use of ozone as a component of treatment complex improves perinatal adaptation of newborn children.
Inflammatory diseases of pelvic organs i.e. internal genitals being considered one of the most frequent pathologies of the woman's body require a new therapeutic approach due to resistance of microorganisms to available antibiotics, high allergization of human body, immunodeficiency and metabolic disturbances associated with the basic pathology.
As a result of the experiments conducted in vivo the pathogenetically proved and at the same time safe ozone concentration is 1200 mcg/L bubbled into saline solution.
The clinical investigations allow making the following conclusions:
- Ozone therapy for inflammatory diseases of pelvic organs is considered as a component of antioxidant therapy as well as exerts a corrective influence on the cellular and humoral immunity confirmed by an increase in immunoregulative index, a decrease in the level of IgM and circulating immune complexes.
- The addition of medical ozone to the multimodality therapy exerts a positive influence on the clinical appearances of acute inflammatory diseases of pelvic organs providing a detoxication, analgesic and sedative effect that allows considerably reducing the use of appropriate traditional medicaments. This improves immediate results, particularly reduces residuals of inflammation. A decrease in relapse percentage after the use of ozone as a component of pathogenetic therapy speaks in favor of optimization of remote results.
The experimental-clinical investigations into the influence of ozone on the course of inflammatory processes of lower female genital organs have shown that ozone in gas phase at certain concentrations and methods of administration exerts a beneficial influence on the factors of local genital immunity that allows stopping the inflammation.
The well-known antimicrobic properties of ozonized olive oil as found out can be successfully used in the treatment of vulvar dystrophic diseases. Ozone therapy produces not only an anti-inflammatory effect, but also improves tissue trophism, allows rejecting the use of hormonal ointments and laser therapy.
The practice has shown that the method of intravenous drop-by-drop infusions of ozonated saline solution is the most suitable and applicable one for obstetric clinic. Saline solution is the optimal carrying agent of ozone as it does not undergo any chemical conversions during the ozonization. Ozonated saline solution is produced by conveying an ozone-oxygen gas mixture through a standard glass bottle with 400 ml of sterile 0,9% sodium chloride solution for 15-20 minutes (by using a 200 ml bottle the ozonization lasts for 10-15 minutes).
With consideration for instability of ozone in aqueous medium, the ozonated saline solution should be used immediately after its production. It is recommended to administer the ozonated saline solution in the form of drips into the cubital vein at a flow rate of 8-10 ml per minute similar to flow infusions that ensures a minimum loss of ozone.
The well-known antimicrobic properties of ozonized olive oil as found out can be successfully used in the treatment of vulvar dystrophic diseases. Ozone therapy produces not only an anti-inflammatory effect, but also improves tissue trophism, allows rejecting the use of hormonal ointments and laser therapy.
The practice has shown that the method of intravenous drop-by-drop infusions of ozonated saline solution is the most suitable and applicable one for obstetric clinic. Saline solution is the optimal carrying agent of ozone as it does not undergo any chemical conversions during the ozonization. Ozonated saline solution is produced by conveying an ozone-oxygen gas mixture through a standard glass bottle with 400 ml of sterile 0,9% sodium chloride solution for 15-20 minutes (by using a 200 ml bottle the ozonization lasts for 10-15 minutes).
With consideration for instability of ozone in aqueous medium, the ozonated saline solution should be used immediately after its production. It is recommended to administer the ozonated saline solution in the form of drips into the cubital vein at a flow rate of 8-10 ml per minute similar to flow infusions that ensures a minimum loss of ozone.
With consideration for dose-related effects of ozone, it is necessary to strictly follow the given mode of ozonization. The safety measures are usual for intravenous infusions.
The method of intravenous drop-by-drop infusions of ozonated saline solution has proved very well in the treatment of inflammatory diseases of pelvic organs as well. Systemic ozone therapy can be also provided in the form of flow rectal insufflations of an ozone/oxygen gas mixture.
In case of inflammatory process in uterine or vaginal cavity it is possible to use the antimicrobic effect of ozone in different variants of its local application (as a carrying agent of ozone can be used distilled water, purified olive oil, ozone therapy in gas phase is possible too).
Ozonized distilled water is produced like the ozonated saline solution, but with consideration that the half-life of ozone in distilled water is more (1,5-2 hrs); therefore the ozonized distilled water keeps its properties longer than the ozonated saline solution.
Production of ozonized olive oil requires more time due to lower solubility of ozone in olive oil and depends on the volume of oil produced (ozone saturation of 100 ml of oil lasts for 2 hrs). It is recommended to use the ready-made ozonized olive oil O'THREE-Ozonide.
The method of intravenous drop-by-drop infusions of ozonated saline solution has proved very well in the treatment of inflammatory diseases of pelvic organs as well. Systemic ozone therapy can be also provided in the form of flow rectal insufflations of an ozone/oxygen gas mixture.
In case of inflammatory process in uterine or vaginal cavity it is possible to use the antimicrobic effect of ozone in different variants of its local application (as a carrying agent of ozone can be used distilled water, purified olive oil, ozone therapy in gas phase is possible too).
Ozonized distilled water is produced like the ozonated saline solution, but with consideration that the half-life of ozone in distilled water is more (1,5-2 hrs); therefore the ozonized distilled water keeps its properties longer than the ozonated saline solution.
Production of ozonized olive oil requires more time due to lower solubility of ozone in olive oil and depends on the volume of oil produced (ozone saturation of 100 ml of oil lasts for 2 hrs). It is recommended to use the ready-made ozonized olive oil O'THREE-Ozonide.
The use of ozone in gas phase is possible by means of special attachments as demonstrated below:
Fig. 1. Attachment for vaginal ozone therapy
- Ozone/oxygen gas inflow
- Ozone/oxygen gas outflow
- Vaginal speculum of Kusko type
- Ozone/oxygen gas mixture
Vaginal catheter
Intravaginal tip
Fig. 2. Functional schema of intravaginal continuous-flow insufflations with O2/O3 gas mixtures
1. Medical ozone generator
2. Vaginal speculum in construction
3. Vacuum suction pump
4. Destructor for residual ozone
2. Vaginal speculum in construction
3. Vacuum suction pump
4. Destructor for residual ozone
Literature for Download
Ozone Therapy
In Different Fields Of Medicine
In Different Fields Of Medicine
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FAQ
You've brought up the problem of toxic impurities possibly containing in the delivered ozone/oxygen mixture. Is it really so important?
Every doctor using ozone therapy must be sure of its safety, thus there must be no doubt about the purity of delivered ozone/oxygen gas mixtures for medical use (they should be contaminant-free).
We consider this problem as very important. It is a fact that after approx. 100 hours of continuous operation owing to the electrochemical erosion of the ozonization chamber walls and electrodes some of available ozone generators deliver an ozone/oxygen gas mixture contaminated by impurities (calcium, aluminium, silicon, magnesium, copper etc) in concentrations considered as dangerous for the health that however can become evident even some months or years after the treatment. This claim is valid through the investigation of the upper layer taken from the ozonization chamber wall. There are only two possible reasons for the products which were found out on the wall:
Parenteral methods of ozone therapy are safe only if the ozone generator delivers pure contaminant-free medical ozone. Each medical ozone generator should be equipped with a filter for extra purification of oxygen used; purity of delivered ozone/oxygen gas mixtures should be guaranteed by the manufacturer through available test protocols, the same is about accuracy in maintaining the chosen ozone concentration (not worse than 10%) and great operation resource (durability) of ozonization chamber (without any decrease in the ozone production and without any change in ozone concentration accuracy) for at least 2000 hours of continuous operation.
We consider this problem as very important. It is a fact that after approx. 100 hours of continuous operation owing to the electrochemical erosion of the ozonization chamber walls and electrodes some of available ozone generators deliver an ozone/oxygen gas mixture contaminated by impurities (calcium, aluminium, silicon, magnesium, copper etc) in concentrations considered as dangerous for the health that however can become evident even some months or years after the treatment. This claim is valid through the investigation of the upper layer taken from the ozonization chamber wall. There are only two possible reasons for the products which were found out on the wall:
- Destruction of the electrodes (the discovered products are equivalent to the materials of electrodes);
- Fine contaminants possibly containing in oxygen which during the ozonolysis can be converted into toxic products.
Parenteral methods of ozone therapy are safe only if the ozone generator delivers pure contaminant-free medical ozone. Each medical ozone generator should be equipped with a filter for extra purification of oxygen used; purity of delivered ozone/oxygen gas mixtures should be guaranteed by the manufacturer through available test protocols, the same is about accuracy in maintaining the chosen ozone concentration (not worse than 10%) and great operation resource (durability) of ozonization chamber (without any decrease in the ozone production and without any change in ozone concentration accuracy) for at least 2000 hours of continuous operation.
What do you think about oxygen concentrators used as Oxygen Supply Systems for medical ozone generators?
There is no definite opinion at this point. Oxygen produced by these devices very seldom reaches the purity of 95% and higher, and we don not know whether the remaining 5% of content would not be dangerous due to electric synthesis in the ozonization chamber or interaction with ozone.
As you know, medical ozone generators require the use of medical oxygen referred to oxygen gas with guaranteed purity of 99,9% and higher. Anyways, we do not mind the use of oxygen concentrators for external i.e. local methods of ozone therapy.
As you know, medical ozone generators require the use of medical oxygen referred to oxygen gas with guaranteed purity of 99,9% and higher. Anyways, we do not mind the use of oxygen concentrators for external i.e. local methods of ozone therapy.
Would you please explain a necessity for a built-in oxygen filter in medical ozone generators?
Our previous experience has shown that oxygen used can contain micro-quantities of technical oils, thus each ozone generator intended for medical use should be equipped with a filter for extra purification of oxygen that inhibits the introduction of technical oils possibly containing in oxygen into the ozonization chamber. During the ozonolysis technical oils can be converted into dangerous toxic products (fatty acids, ketones, aldehydes etc).
Within a long operation time of ozone generator great volumes of oxygen are conveyed through the ozonization chamber (within 100 hours of operation in case of saline ozonization at a flow-rate of 1 L/min approx. 6000 L of oxygen are conveyed through the ozonization chamber), the ozonization chamber gradually becomes covered with an oily layer, and the doctor cannot be sure of the quality of gas mixtures delivered, thus extra purification of oxygen through a filter at the inlet of ozone generator is a reasonable step.
Within a long operation time of ozone generator great volumes of oxygen are conveyed through the ozonization chamber (within 100 hours of operation in case of saline ozonization at a flow-rate of 1 L/min approx. 6000 L of oxygen are conveyed through the ozonization chamber), the ozonization chamber gradually becomes covered with an oily layer, and the doctor cannot be sure of the quality of gas mixtures delivered, thus extra purification of oxygen through a filter at the inlet of ozone generator is a reasonable step.
Would you please explain the parameter "Range of selecting the dose of ozone"?
It is puzzling to us that some manufacturers of medical ozone generators use the parameter "Ozone production per 1 hour". This parameter was obviously taken from the ozone technology for water treatment, but in the medicine the ozone production should be adjustable at least per 1 min
How important is the accuracy of +/-5% … +/-10% in maintaining the chosen ozone concentration and the adjustable range 1 : 9950, as far as I know, recently these parameters have not been taken into consideration?
Before the New-Generation of medical ozone machines characterized by unique accuracy in maintaining the chosen ozone concentration and a uniquely wide range of ozone concentration adjustment, the doctors using ozone therapy were conditioned by the "traditional" types of ozone generator with very low accuracy in maintaining the chosen ozone concentration (worse than 40-50% as a rule) and a narrow adjustable range (1 : 15 - from 1 mg/l to 15 mg/l). The ozone concentration accuracy of +/-5% …+/-10% ensures a reasonable, predictable and dose-related therapy.
The high accuracy in maintaining the chosen ozone concentration allows using ozone like any other generally accepted medicine. That might have been one of the obstacles for wide spreading of ozone therapy. Nevertheless, all advantages of the Medozons machine do not influence its price, but this is a fact that there are many medical ozone generators on the market being much more expensive, but inferior in technical properties as compared with our machines.
The high accuracy in maintaining the chosen ozone concentration allows using ozone like any other generally accepted medicine. That might have been one of the obstacles for wide spreading of ozone therapy. Nevertheless, all advantages of the Medozons machine do not influence its price, but this is a fact that there are many medical ozone generators on the market being much more expensive, but inferior in technical properties as compared with our machines.
The parameters "Range of ozone concentration adjustment 1:9950" and "Range of selecting the dose of ozone 0,25 … 10000" are not clear to us.
Would you please explain it?
Would you please explain it?
We can explain it with the Medozons-BM:
So, medical ozone generators of Medozons series are able to produce guaranteed pure medical ozone and dose it exactly, with regards to technical and medical features they are the best ones within Russia and have no analogies worldwide! We are sure that the above parameters today considered as unique tomorrow will be the new standards of ozone therapy.
- Range of delivered ozone concentrations (50…10 000) mcg/L. This parameter means that the machine is able to maintain the chosen ozone concentration within the available range with accuracy not worse than +/- 10%: 107 mcg/L or 5671 mcg/L.
- The parameter "Range of ozone concentration adjustment (1 : 9950)" means that the machine is able to provide 9950 values/gradations of ozone concentration with accuracy +/-10% that characterizes the depth of adjustment.
- The range of selecting the dose of ozone characterizes a wide range of ozone dosage adjustment from 0,25 mcg/L to 10000 mcg/L with accuracy +/-5%, at an ozone/oxygen flow-rate of 0,25 L/min adjustable by step 0,25 mcg; 0,5 L/min - 0,5 mcg; 1 L/min - 1 mcg.
So, medical ozone generators of Medozons series are able to produce guaranteed pure medical ozone and dose it exactly, with regards to technical and medical features they are the best ones within Russia and have no analogies worldwide! We are sure that the above parameters today considered as unique tomorrow will be the new standards of ozone therapy.
Would you please explain a necessity for an automated system of ozone-oxygen flow-rate adjustment, what about doing it manually by means of oxygen flow regulator? The use of fixed flow-rates (0,25; 0,5; 1,0 L/min) may limit the range of ozone applications.
Manually setting of oxygen flow-rate by means of regulator may induce a considerable decrease in ozone dosage accuracy (the dose of ozone = CO3 x O2/O3 flow-rate x treatment time) due to possible oxygen pressure fluctuations (in oxygen tank or any other oxygen supply system) or any change in gas tract resistance.
In medical ozone generators of Medozons series oxygen flow-rate delivered to the ozonization chamber is automatically stabilized at the given level regardless of influence from outside, the automated stabilization system of oxygen flow-rate is reliable even in case of considerable pressure fluctuations that ensures a dose-related therapy. The automatic gas supply system is tested by the manufacturer for accuracy in maintaining the chosen oxygen flow-rate. We are convinced that the fixed O2/O3 flow-rates do not limit, but widen the range of ozone applications, most of doctors perform ozone therapy at a flow-rate of 1 L/min, but using a flow-rate of 0,5 or 0,25 L/min it is possible to successfully perform intracavitary ozone therapy (in gynecology, urology etc).
In medical ozone generators of Medozons series oxygen flow-rate delivered to the ozonization chamber is automatically stabilized at the given level regardless of influence from outside, the automated stabilization system of oxygen flow-rate is reliable even in case of considerable pressure fluctuations that ensures a dose-related therapy. The automatic gas supply system is tested by the manufacturer for accuracy in maintaining the chosen oxygen flow-rate. We are convinced that the fixed O2/O3 flow-rates do not limit, but widen the range of ozone applications, most of doctors perform ozone therapy at a flow-rate of 1 L/min, but using a flow-rate of 0,5 or 0,25 L/min it is possible to successfully perform intracavitary ozone therapy (in gynecology, urology etc).
How would you explain the fact that your ozone generators are not equipped with a measuring device to determine the delivered ozone concentration? To my mind, this can discredit the method of ozone therapy. From my own experience I know that at the starting point any medical ozone generator has the actual accuracy of delivered ozone concentration +/-40…+/-80%.
In medical ozone generators of Medozons series like Medozons-BM and BM-02 you can see a different functional principle of the ozonization chamber that ensures a wide range of ozone concentration adjustment (from 50 to 10000 mcg/L) with high accuracy in automatically maintaining the chosen ozone concentration not worse than +/- 10%, in fact, the actual accuracy tested by the manufacturer is not worse than +/- 5%. The attested accuracy is valid for at least the same time as the specified durability of the ozonization chamber before the scheduled prophylactic service (2000 hours of continuous operation or about 5 years of usage). The latest device Medozons-System has a built-in measurer of ozone concentratrions.
© MEDOZONS Ltd., 2009
Ul. B.Panina 9 * 603089 Nizhny Novgorod / Russia
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N.B. The information on our website is intended for medical professionals, since ozone therapy and medical ozone generators should be used in a clinical setting under the supervision of a medical doctor.