Equipment and Accessories for Modern High-Effective Technology of Ozone Therapy and Ozone prophylaxis
Equipment and Accessories for Modern High-Effective Technology of Ozone Therapy and Ozone prophylaxis
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Ozone Therapy in Other Fields
Ozone Therapy in the Clinic of ENT (Ear, Nose, Throat) Diseases
In the otorhinolaryngological praxis medical ozone is primarily used as a therapeutic agent with powerful bactericidal, virucidal, fungicidal properties, detoxification effect in the treatment of suppurative inflammatory diseases of ENT organs with consideration to their polyetiological factor. It also performs an important role in the stimulation of pagocytosis and regulation of cellular and humoral immunity.
In acute and chronic maxillary sinusitis it is recommended to use ozonated 0,9% sodium chloride solution for rinsing of maxillary sinuses through a catheter. (S.V.Pestov etc, 1998). The beginning of local ozone therapy induces an aggravation of inflammatory process in the mucous membrane of maxillary sinus (an increase in the neutrophiles in washing solution removed from the sinus). On the 3rd-5th day of therapy the "neutrophile" phase is changing to the "reparative" one, it comes to general improvement, normalization in the indices of peripheral blood (A.B.Terentyeva, 1998). At the same time the patients receive minor autohaemotherapy with 200 mcg of ozone every two days, 4-6 procedures per one treatment course.
The conservative treatment of different forms of chronic tonsillitis includes systemic and local methods of oxidative therapy. The treatment course is repeated twice a year. The systemic treatment is carried out in the form of parenteral infusion of 200-400 ml of ozonated physiological saline at ozone concentration of 1000 mcg/L, 5 procedures per one treatment course every two days.
In acute and chronic maxillary sinusitis it is recommended to use ozonated 0,9% sodium chloride solution for rinsing of maxillary sinuses through a catheter. (S.V.Pestov etc, 1998). The beginning of local ozone therapy induces an aggravation of inflammatory process in the mucous membrane of maxillary sinus (an increase in the neutrophiles in washing solution removed from the sinus). On the 3rd-5th day of therapy the "neutrophile" phase is changing to the "reparative" one, it comes to general improvement, normalization in the indices of peripheral blood (A.B.Terentyeva, 1998). At the same time the patients receive minor autohaemotherapy with 200 mcg of ozone every two days, 4-6 procedures per one treatment course.
The conservative treatment of different forms of chronic tonsillitis includes systemic and local methods of oxidative therapy. The treatment course is repeated twice a year. The systemic treatment is carried out in the form of parenteral infusion of 200-400 ml of ozonated physiological saline at ozone concentration of 1000 mcg/L, 5 procedures per one treatment course every two days.
The local treatment is performed as rinsing of lacunae of faucial tonsils with isotonic sodium chloride solution bubbled with ozone at concentration of 10000 mcg/L, 500 ml of solution per one procedure. After 3-4 procedures it comes to disappearance of pain, general intoxication, cleaning of lacunae from deitritis, decrease in the size of faucial tonsils (I.I.Akulich etc, 2000).
For treatment of chronic middle otitis it is recommended to use a complex ozone therapy. Along with bactericidal effect, the local use of ozonated physiological saline at ozone concentration of 7000-10000 mcg/L facilitates a decrease in the destructive phase of inflammation, reduces a risk of formation of scars and commissures in the tympanum.
The local use of ozonized olive oil "O'THREE-Ozonide" eliminates inflammation of postoperative cavities and facilitates fast epidermization (A.N.Tafintsev etc, 2000). The patients with intoxication symptoms receive parenteral infusions of ozonated physiological saline at a volume of 200 ml and ozone concentration of 1000-2000 mcg/L every two days, 5-7 procedures per one treatment course.
After 3-4 procedures it comes to stopping of pyorrhea, elimination of pain syndrome, decrease in intoxication, decreased growth of pathogenic flora or its disappearance (A.N.Tafintsev etc, 2000).
For treatment of chronic middle otitis it is recommended to use a complex ozone therapy. Along with bactericidal effect, the local use of ozonated physiological saline at ozone concentration of 7000-10000 mcg/L facilitates a decrease in the destructive phase of inflammation, reduces a risk of formation of scars and commissures in the tympanum.
The local use of ozonized olive oil "O'THREE-Ozonide" eliminates inflammation of postoperative cavities and facilitates fast epidermization (A.N.Tafintsev etc, 2000). The patients with intoxication symptoms receive parenteral infusions of ozonated physiological saline at a volume of 200 ml and ozone concentration of 1000-2000 mcg/L every two days, 5-7 procedures per one treatment course.
After 3-4 procedures it comes to stopping of pyorrhea, elimination of pain syndrome, decrease in intoxication, decreased growth of pathogenic flora or its disappearance (A.N.Tafintsev etc, 2000).
Ozone therapy is considered a pathogenetically verified method in the treatment of sensorineural pathology as the main link of pathogenesis of deafness is cochlea hypoxia associated with vascular, toxic and other pathological conditions. Along with generally accepted methods of treatment, N.A.Miroshnichenko recommends to use intravenous infusions of ozonated physiological saline at volume of 400 ml and ozone concentration of 1000 mcg/L every two days, total number - 5-7 procedures. The complementary use of ozone therapy facilitates faster normalization of general condition, improvement of hearing or disappearance of noise in the ears, intensification of reparative processes, stimulation of intracellular synthesis of antioxidants.
Major trauma of ENT tissues due to firearm injury causes an explosion of lipid peroxidation processes and decompensation of antioxidant defense. The considerable blood lost leads to tissue hypoxia and weakening of the organism's immune defense, wound infection with microflora resistant to antibiotics and antiseptics. Suppuration of wounds can lead to more threatening complications.
The use of oxidative therapy in the complex treatment of ENT wounds facilitates a faster restoration of haemodynamical disturbances, elimination of tissue hypoxia, elimination of misbalance of oxidoreduction processes.
Major trauma of ENT tissues due to firearm injury causes an explosion of lipid peroxidation processes and decompensation of antioxidant defense. The considerable blood lost leads to tissue hypoxia and weakening of the organism's immune defense, wound infection with microflora resistant to antibiotics and antiseptics. Suppuration of wounds can lead to more threatening complications.
The use of oxidative therapy in the complex treatment of ENT wounds facilitates a faster restoration of haemodynamical disturbances, elimination of tissue hypoxia, elimination of misbalance of oxidoreduction processes.
The preparation for surgery includes the use of intravenous infusions at volume of 400 ml of ozonated physiological saline and ozone concentration of 2000 mcg/L. During the operation the patient receives 200 ml of ozone-enriched blood of the same group. The postoperative treatment includes rinsing of wounds and mucosa at the damaged area with ozonated physiological saline at bactericidal concentrations of 5000-10000 mcg/L (I.I.Akulich, S.V.Semenov, 2000). This therapeutic complex considerably reduces the number of complications, shortens treatment duration and improves the outcomes of injury. In the ophthalmology medical ozone is used in the complex of therapeutic modalities at the early stage of Leber's optic athrophy and retinal dystrophy of I-II grade. Thanks to variety of mechanisms of its therapeutic action: improvement of metabolism with increase of pO2 (intensification of oxidoreduction extra- and intracellular processes, synthesis of biologically active substances) it comes to a positive result in the treatment of diseases usually associated with serious difficulties. Ozone therapy is carried out in the form of intravenous infusions (drips) of ozonated physiological saline at ozone concentration of 800-1000 mcg/L.
One treatment course consists of 5-6 infusions every two days (N.L.Malanova etc, 1995). The results of the performed oxidative therapy manifest as an increase in eyesight sharpness. Any side effects of treatment have been not observed.
One treatment course consists of 5-6 infusions every two days (N.L.Malanova etc, 1995). The results of the performed oxidative therapy manifest as an increase in eyesight sharpness. Any side effects of treatment have been not observed.
Ozone Therapy in the Addictology
The applicability of medical ozone in the addictology is explained by its ability to synthesize the biologically active substances (catecholamin, serotonin, histamine etc), initiate the endogenous detoxification mechanisms (utilization of the underoxidated products, restoration of pH, decrease in the end products of nitrogen metabolism, improvement in the function of liver, kidney, lung) at the level of the whole organism that results in the improvement of the oxygen-transport function of blood.
In the addictology it is recommended to use the systemic methods of ozone therapy: intravenous infusions (drips) of ozonated physiological saline, major autohaemotherapy with ozone, rectal ozone insufflations.
Treatment should be started with intestinal cleansing (the apparative one is preferable) with the follow-up introduction of ozone/oxygen gas mixture per rectum at a volume of 300 ml and ozone concentration of 3000 mcg/L.
In the addictology it is recommended to use the systemic methods of ozone therapy: intravenous infusions (drips) of ozonated physiological saline, major autohaemotherapy with ozone, rectal ozone insufflations.
Treatment should be started with intestinal cleansing (the apparative one is preferable) with the follow-up introduction of ozone/oxygen gas mixture per rectum at a volume of 300 ml and ozone concentration of 3000 mcg/L.
One treatment course consists of 6-8 procedures every two days. In combination with rectal ozone insufflations the patient receives intravenous infusions (drips) of ozonated physiological saline at volume of 400-600 ml daily (200 ml 2-3 times a day within the infusion detoxification program). Ozone concentration used for saline bubbling is 1500-2000 mcg/L. In case of hepatic insufficiency infusions of ozonated saline can be replaced by major autohaemotherapy with 1000-2000 mcg of ozone 3 times a week, 8-10 procedures per one treatment course. During the course of ozone therapy it is necessary to use antioxidants in a sufficient quantity.
The use of ozone therapy allows more quickly and effectively to eliminate sever abstinence conditions. It comes to improvement of appetite, normalization of sleep, decrease in the intensity of muscular pain and intoxication symptoms.
The use of ozone therapy allows more quickly and effectively to eliminate sever abstinence conditions. It comes to improvement of appetite, normalization of sleep, decrease in the intensity of muscular pain and intoxication symptoms.
Ozone Therapy in the Sports Medicine
There are many mentions about the great role of ozone therapy in sports medicine including sports traumatology, detoxification, fast restoration within a competition period, ability to reach a sporty shape peak for a short time and keep it as long as necessary.
The erythrocytic mechanism of action of medical ozone (electrophylic addition of erythrocyte membrane to double bonds of unsaturated fatty acids and herewith connected formation of short-chain peroxides, reactive shift of the oxygen-hemoglobin curve to the right, improvement in release of oxygen to peripheral tissues) improves oxygen utilization in the periphery by increasing exercise capacity parameters. The Western ozone doctors use in sports medicine major autohaemotherapy with a total ozone dose of 1000 mcg (three times a week, n = 10), but the Russian ozone doctors recommend to replace major autohaemotherapy with intravenous infusions of ozonated physiological saline (at a volume of 200 ml, ozone concentration of 1200 mcg/L, every two days, n=8). It was observed that through ozone therapy in many professional sportsmen it came to objective signs showing improvement of anaerobic metabolism being important for subjective trainings before competition and shortening of the restorative period. Obvious results come not immediately after the first course of ozone therapy, but often after 2-3 courses as physical adaptation requires some time to react to the given stimulants. An interval between the courses - 4-6 months, it's recommended to perform a course before the competition.
The erythrocytic mechanism of action of medical ozone (electrophylic addition of erythrocyte membrane to double bonds of unsaturated fatty acids and herewith connected formation of short-chain peroxides, reactive shift of the oxygen-hemoglobin curve to the right, improvement in release of oxygen to peripheral tissues) improves oxygen utilization in the periphery by increasing exercise capacity parameters. The Western ozone doctors use in sports medicine major autohaemotherapy with a total ozone dose of 1000 mcg (three times a week, n = 10), but the Russian ozone doctors recommend to replace major autohaemotherapy with intravenous infusions of ozonated physiological saline (at a volume of 200 ml, ozone concentration of 1200 mcg/L, every two days, n=8). It was observed that through ozone therapy in many professional sportsmen it came to objective signs showing improvement of anaerobic metabolism being important for subjective trainings before competition and shortening of the restorative period. Obvious results come not immediately after the first course of ozone therapy, but often after 2-3 courses as physical adaptation requires some time to react to the given stimulants. An interval between the courses - 4-6 months, it's recommended to perform a course before the competition.
According to Prof. Peretyagin ozone therapy can be successfully used at different stages of the competition period:
Among our customers (users of our ozone machines) there are sports doctors of many professional teams, for example, in cycle racing, ice hockey, shooting etc. For understanding reasons the successfully acting sports doctors do not publish their results on anti-doping programs and other information regarding trainings of sportsmen, particularly in professional sports.
Anyhow there are many publications on ozone therapy that can be applied to sports medicine as well (on detoxification, increase in exercise capacity, immunorehabilitation, restoration of shape, traumatology etc.).
- pre-competition period, pre-season trainings. Of great importance is intensification of metabolic processes, enzymatic systems. Ozone introduced by parenteral way acts like a specific biostimulator.
- re-adaptation within the competition period. Of great importance is powerful oxidative detoxification provided through ozone therapy.
- restoration after the competition period characterized by physical, nervous and psychic exhaustion of the organism.
Among our customers (users of our ozone machines) there are sports doctors of many professional teams, for example, in cycle racing, ice hockey, shooting etc. For understanding reasons the successfully acting sports doctors do not publish their results on anti-doping programs and other information regarding trainings of sportsmen, particularly in professional sports.
Anyhow there are many publications on ozone therapy that can be applied to sports medicine as well (on detoxification, increase in exercise capacity, immunorehabilitation, restoration of shape, traumatology etc.).
Ozone Therapy
In Different Fields Of Medicine
In Different Fields Of Medicine
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FAQ
You've brought up the problem of toxic impurities possibly containing in the delivered ozone/oxygen mixture. Is it really so important?
Every doctor using ozone therapy must be sure of its safety, thus there must be no doubt about the purity of delivered ozone/oxygen gas mixtures for medical use (they should be contaminant-free).
We consider this problem as very important. It is a fact that after approx. 100 hours of continuous operation owing to the electrochemical erosion of the ozonization chamber walls and electrodes some of available ozone generators deliver an ozone/oxygen gas mixture contaminated by impurities (calcium, aluminium, silicon, magnesium, copper etc) in concentrations considered as dangerous for the health that however can become evident even some months or years after the treatment. This claim is valid through the investigation of the upper layer taken from the ozonization chamber wall. There are only two possible reasons for the products which were found out on the wall:
Parenteral methods of ozone therapy are safe only if the ozone generator delivers pure contaminant-free medical ozone. Each medical ozone generator should be equipped with a filter for extra purification of oxygen used; purity of delivered ozone/oxygen gas mixtures should be guaranteed by the manufacturer through available test protocols, the same is about accuracy in maintaining the chosen ozone concentration (not worse than 10%) and great operation resource (durability) of ozonization chamber (without any decrease in the ozone production and without any change in ozone concentration accuracy) for at least 2000 hours of continuous operation.
We consider this problem as very important. It is a fact that after approx. 100 hours of continuous operation owing to the electrochemical erosion of the ozonization chamber walls and electrodes some of available ozone generators deliver an ozone/oxygen gas mixture contaminated by impurities (calcium, aluminium, silicon, magnesium, copper etc) in concentrations considered as dangerous for the health that however can become evident even some months or years after the treatment. This claim is valid through the investigation of the upper layer taken from the ozonization chamber wall. There are only two possible reasons for the products which were found out on the wall:
- Destruction of the electrodes (the discovered products are equivalent to the materials of electrodes);
- Fine contaminants possibly containing in oxygen which during the ozonolysis can be converted into toxic products.
Parenteral methods of ozone therapy are safe only if the ozone generator delivers pure contaminant-free medical ozone. Each medical ozone generator should be equipped with a filter for extra purification of oxygen used; purity of delivered ozone/oxygen gas mixtures should be guaranteed by the manufacturer through available test protocols, the same is about accuracy in maintaining the chosen ozone concentration (not worse than 10%) and great operation resource (durability) of ozonization chamber (without any decrease in the ozone production and without any change in ozone concentration accuracy) for at least 2000 hours of continuous operation.
What do you think about oxygen concentrators used as Oxygen Supply Systems for medical ozone generators?
There is no definite opinion at this point. Oxygen produced by these devices very seldom reaches the purity of 95% and higher, and we don not know whether the remaining 5% of content would not be dangerous due to electric synthesis in the ozonization chamber or interaction with ozone.
As you know, medical ozone generators require the use of medical oxygen referred to oxygen gas with guaranteed purity of 99,9% and higher. Anyways, we do not mind the use of oxygen concentrators for external i.e. local methods of ozone therapy.
As you know, medical ozone generators require the use of medical oxygen referred to oxygen gas with guaranteed purity of 99,9% and higher. Anyways, we do not mind the use of oxygen concentrators for external i.e. local methods of ozone therapy.
Would you please explain a necessity for a built-in oxygen filter in medical ozone generators?
Our previous experience has shown that oxygen used can contain micro-quantities of technical oils, thus each ozone generator intended for medical use should be equipped with a filter for extra purification of oxygen that inhibits the introduction of technical oils possibly containing in oxygen into the ozonization chamber. During the ozonolysis technical oils can be converted into dangerous toxic products (fatty acids, ketones, aldehydes etc).
Within a long operation time of ozone generator great volumes of oxygen are conveyed through the ozonization chamber (within 100 hours of operation in case of saline ozonization at a flow-rate of 1 L/min approx. 6000 L of oxygen are conveyed through the ozonization chamber), the ozonization chamber gradually becomes covered with an oily layer, and the doctor cannot be sure of the quality of gas mixtures delivered, thus extra purification of oxygen through a filter at the inlet of ozone generator is a reasonable step.
Within a long operation time of ozone generator great volumes of oxygen are conveyed through the ozonization chamber (within 100 hours of operation in case of saline ozonization at a flow-rate of 1 L/min approx. 6000 L of oxygen are conveyed through the ozonization chamber), the ozonization chamber gradually becomes covered with an oily layer, and the doctor cannot be sure of the quality of gas mixtures delivered, thus extra purification of oxygen through a filter at the inlet of ozone generator is a reasonable step.
Would you please explain the parameter "Range of selecting the dose of ozone"?
It is puzzling to us that some manufacturers of medical ozone generators use the parameter "Ozone production per 1 hour". This parameter was obviously taken from the ozone technology for water treatment, but in the medicine the ozone production should be adjustable at least per 1 min
How important is the accuracy of +/-5% … +/-10% in maintaining the chosen ozone concentration and the adjustable range 1 : 9950, as far as I know, recently these parameters have not been taken into consideration?
Before the New-Generation of medical ozone machines characterized by unique accuracy in maintaining the chosen ozone concentration and a uniquely wide range of ozone concentration adjustment, the doctors using ozone therapy were conditioned by the "traditional" types of ozone generator with very low accuracy in maintaining the chosen ozone concentration (worse than 40-50% as a rule) and a narrow adjustable range (1 : 15 - from 1 mg/l to 15 mg/l). The ozone concentration accuracy of +/-5% …+/-10% ensures a reasonable, predictable and dose-related therapy.
The high accuracy in maintaining the chosen ozone concentration allows using ozone like any other generally accepted medicine. That might have been one of the obstacles for wide spreading of ozone therapy. Nevertheless, all advantages of the Medozons machine do not influence its price, but this is a fact that there are many medical ozone generators on the market being much more expensive, but inferior in technical properties as compared with our machines.
The high accuracy in maintaining the chosen ozone concentration allows using ozone like any other generally accepted medicine. That might have been one of the obstacles for wide spreading of ozone therapy. Nevertheless, all advantages of the Medozons machine do not influence its price, but this is a fact that there are many medical ozone generators on the market being much more expensive, but inferior in technical properties as compared with our machines.
The parameters "Range of ozone concentration adjustment 1:9950" and "Range of selecting the dose of ozone 0,25 … 10000" are not clear to us.
Would you please explain it?
Would you please explain it?
We can explain it with the Medozons-BM:
So, medical ozone generators of Medozons series are able to produce guaranteed pure medical ozone and dose it exactly, with regards to technical and medical features they are the best ones within Russia and have no analogies worldwide! We are sure that the above parameters today considered as unique tomorrow will be the new standards of ozone therapy.
- Range of delivered ozone concentrations (50…10 000) mcg/L. This parameter means that the machine is able to maintain the chosen ozone concentration within the available range with accuracy not worse than +/- 10%: 107 mcg/L or 5671 mcg/L.
- The parameter "Range of ozone concentration adjustment (1 : 9950)" means that the machine is able to provide 9950 values/gradations of ozone concentration with accuracy +/-10% that characterizes the depth of adjustment.
- The range of selecting the dose of ozone characterizes a wide range of ozone dosage adjustment from 0,25 mcg/L to 10000 mcg/L with accuracy +/-5%, at an ozone/oxygen flow-rate of 0,25 L/min adjustable by step 0,25 mcg; 0,5 L/min - 0,5 mcg; 1 L/min - 1 mcg.
So, medical ozone generators of Medozons series are able to produce guaranteed pure medical ozone and dose it exactly, with regards to technical and medical features they are the best ones within Russia and have no analogies worldwide! We are sure that the above parameters today considered as unique tomorrow will be the new standards of ozone therapy.
Would you please explain a necessity for an automated system of ozone-oxygen flow-rate adjustment, what about doing it manually by means of oxygen flow regulator? The use of fixed flow-rates (0,25; 0,5; 1,0 L/min) may limit the range of ozone applications.
Manually setting of oxygen flow-rate by means of regulator may induce a considerable decrease in ozone dosage accuracy (the dose of ozone = CO3 x O2/O3 flow-rate x treatment time) due to possible oxygen pressure fluctuations (in oxygen tank or any other oxygen supply system) or any change in gas tract resistance.
In medical ozone generators of Medozons series oxygen flow-rate delivered to the ozonization chamber is automatically stabilized at the given level regardless of influence from outside, the automated stabilization system of oxygen flow-rate is reliable even in case of considerable pressure fluctuations that ensures a dose-related therapy. The automatic gas supply system is tested by the manufacturer for accuracy in maintaining the chosen oxygen flow-rate. We are convinced that the fixed O2/O3 flow-rates do not limit, but widen the range of ozone applications, most of doctors perform ozone therapy at a flow-rate of 1 L/min, but using a flow-rate of 0,5 or 0,25 L/min it is possible to successfully perform intracavitary ozone therapy (in gynecology, urology etc).
In medical ozone generators of Medozons series oxygen flow-rate delivered to the ozonization chamber is automatically stabilized at the given level regardless of influence from outside, the automated stabilization system of oxygen flow-rate is reliable even in case of considerable pressure fluctuations that ensures a dose-related therapy. The automatic gas supply system is tested by the manufacturer for accuracy in maintaining the chosen oxygen flow-rate. We are convinced that the fixed O2/O3 flow-rates do not limit, but widen the range of ozone applications, most of doctors perform ozone therapy at a flow-rate of 1 L/min, but using a flow-rate of 0,5 or 0,25 L/min it is possible to successfully perform intracavitary ozone therapy (in gynecology, urology etc).
How would you explain the fact that your ozone generators are not equipped with a measuring device to determine the delivered ozone concentration? To my mind, this can discredit the method of ozone therapy. From my own experience I know that at the starting point any medical ozone generator has the actual accuracy of delivered ozone concentration +/-40…+/-80%.
In medical ozone generators of Medozons series like Medozons-BM and BM-02 you can see a different functional principle of the ozonization chamber that ensures a wide range of ozone concentration adjustment (from 50 to 10000 mcg/L) with high accuracy in automatically maintaining the chosen ozone concentration not worse than +/- 10%, in fact, the actual accuracy tested by the manufacturer is not worse than +/- 5%. The attested accuracy is valid for at least the same time as the specified durability of the ozonization chamber before the scheduled prophylactic service (2000 hours of continuous operation or about 5 years of usage). The latest device Medozons-System has a built-in measurer of ozone concentratrions.
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