Potential use of ozone in SARS-CoV-2 / COVID-19. Official Expert Opinion of the International Scientific Committee of Ozone Therapy (ISCO3). ISCO3/EPI/00/04 (March 14, 2020). Approved by ISCO3 on 13/03/2020.Original drafters of the paper: Adriana Schwartz, Scientific Secretary of ISCO3, Gregorio Martínez-Sánchez, President of ISCO3.

Index

Disclaimer
Abbreviation / Acronyms
Summary
Keywords
Introduction
Environmental disinfection
Therapeutic actions of ozone in viral diseases
Recommended administration route
Recommended clinical protocol with O3SS
Preventive protocol with O3SS
Interventional protocol with O3SS
Devices (Ozone Generators and Disposables)
Concluding Remarks
References

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FAQ

Every doctor using ozone therapy must be sure of its safety, thus there must be no doubt about the purity of delivered ozone/oxygen gas mixtures for medical use (they should be contaminant-free).

We consider this problem as very important. It is a fact that after approx. 100 hours of continuous operation owing to the electrochemical erosion of the ozonization chamber walls and electrodes some of available ozone generators deliver an ozone/oxygen gas mixture contaminated by impurities (calcium, aluminium, silicon, magnesium, copper etc) in concentrations considered as dangerous for the health that however can become evident even some months or years after the treatment. This claim is valid through the investigation of the upper layer taken from the ozonization chamber wall. There are only two possible reasons for the products which were found out on the wall:

Destruction of the electrodes (the discovered products are equivalent to the materials of electrodes);
Fine contaminants possibly containing in oxygen which during the ozonolysis can be converted into toxic products.

A decrease in the ozone production can be considered as a starting point for destruction of the ozonization chamber wall (after approx. 100 hours of continuous operation). The so-called "traditional" ozone generators should be used very carefully, particularly for parenteral ozone therapy in the form of intravenous infusions of ozonated saline that can serve as ideal medium for fine contaminants.

Parenteral methods of ozone therapy are safe only if the ozone generator delivers pure contaminant-free medical ozone. Each medical ozone generator should be equipped with a filter for extra purification of oxygen used; purity of delivered ozone/oxygen gas mixtures should be guaranteed by the manufacturer through available test protocols, the same is about accuracy in maintaining the chosen ozone concentration (not worse than 10%) and great operation resource (durability) of ozonization chamber (without any decrease in the ozone production and without any change in ozone concentration accuracy) for at least 2000 hours of continuous operation.

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